The inverse relationship of osteoporosis and osteoarthritis!!

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The similarity of etiology:
The etiology of osteoporosis (OP) and osteoarthritis (OA) is multi-factorial: constitutional and environmental factors, ranging from genetic susceptibility, endocrine and metabolic status, to mechanical and traumatic injury, are thought to be involved.
The differences:
1. The anthropometric differences of patients suffering from OA compared with OP are well established. OA cases have stronger body build and are more obese. OA cases have increased BMD or BMC at all sites. OA cases not only have higher apparent and real bone density, but also wider geometrical measures of the skeleton, diameters of long bones and trabeculae, both contributing positively to better strength and fewer fragility fractures.
2. Not only is bone quantity in OA different but also bone quality, compared with controls and OP cases, with increased content of growth factors such as IGF and TGFbeta, factors required for bone repair.
3. Furthermore, in vitro studies of osteoblasts recruited from OA bone have different differentiation patterns and phenotypes. These general bone characteristics of OA bone may explain the inverse relationship OA-OP and why OA cases have fewer fragility fractures.

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