Chemical mediators of pain due to disc injury
Authors such as McKenzie have emphasized distinct pain patterns attributable to mechanical & chemical origin within the scope of mechanical spinal disorders. It is easily understood that disc injury produces pain by mechanical effect. However, injured discs can produce chemical mediators of pain. Not only this, these chemical mediators can lead to degeneration of the disc itself. Interestingly biochemical events that occur with intervertebral disc degeneration and, in particular, the role of biochemical mediators of inflammation and tissue degradation have received sparse attention in the literature. Kang et al obtained herniated lumbar & cervical disc specimens from patients undergoing surgical discectomy for persistent radiculopathy. They found biochemical mediators of inflammation due to tissue degradation play a role in intervertebral disc degeneration and in the pathophysiology of radiculopathy. Herniated lumbar & cervical discs were producing spontaneously increased a...