Change in pain biomarkers after OMT

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Underlying mechanisms explaining the effects of osteopathic manipulative treatment (OMT) are poorly defined. Change in various nociceptive (pain) biomarkers that have been suggested as important mediators in this process. A pilot study by Degenhardt BF et al on 20 subjects (10 with chronic low back pain, 10 controls without chronic LBP) if OMT influences levels of circulatory pain biomarkers reveals that, concentrations of several circulatory pain biomarkers were altered after OMT. The degree and duration of these changes were greater in subjects with chronic LBP than in control subjects without the disorder.

Pain biomarkers used by Degenhardt BF et al are:
1. beta-endorphin (betaE),
2. serotonin (5-hydroxytryptamine [5-HT]),
3. 5-hydroxyindoleacetic acid (5-HIAA),
4. anandamide (arachidonoylethanolamide [AEA]),
5. and N-palmitoylethanolamide (PEA).

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