correlation between aeroic fitness, IMCL, insulin sensitivity in trained & untrained subjects

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Thamer C et al (2003) reported obesity and aerobic fitness are important determinants of intramyocellular lipids (IMCL). Intramyocellular lipids and insulin sensitivity are negatively correlated in untrained subjects. The correlation between the two parameters is modified by the extent of aerobic fitness and cannot be found in endurance trained subjects. Thus, measurements of aerobic fitness and body fat are indispensable for the interpretation of intramyocellular lipids and its relationship with insulin sensitivity.

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