Vertebral fracture cascade and it’s impact

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Once an initial vertebral fracture is sustained, the risk of subsequent vertebral fracture increases significantly. This phenomenon has been termed the "vertebral fracture cascade". Mechanisms underlying this fracture cascade are inadequately understood. Evidence suggests that non-bone parameters differ between individuals with and those without osteoporotic vertebral fractures. Neurophysiologic properties, particularly trunk control and balance, are affected by the presence of a vertebral fracture.

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